Pregnancy Associated Breast Cancer di Rumah Sakit Onkologi Surabaya 2006 2014

JACOBUS OCTOVIANUS* -  , Indonesia
SAVITRI KUNTARI -  , Indonesia
ARIO DJATMIKO -  , Indonesia

DOI : 10.33371/ijoc.v9i2.377

ABSTRACTPregnancy associated breast cancer (PABC) is the most common malignancy in gestation. Due to its high aggressiveness, PABC needs a specific management right from diagnosis process to therapy. The objective of this study is to find out the PABC profile in Rumah Sakit Onkologi Surabaya from 2006-2014. A descriptive study using PABC Medical Record datafrom 2006 until 2014. There were 21 PABC patients of whom 11 was diagnosed on 31-40 years old (52.38%); 16 PABC patients with multiparity (76.19%); 14 (66.67%) PABC diagnosed at 1 year post partum; 18 USG and 6 Mammography examinations, both revealed 100% sensitivity in diagnosing PABC; 14 patients (66,67%) in stadium III-IV; 9 patients (42,86%) with T4 tumor size; 9 patients (42,86%) with axillary lymphnode metastasis ; 4 patients (19,05%) with distant metastasis; 10 patients (47,62%) with Invasive Ductal Carcinoma (IDC); 14 patients (66,67%) grade III; and 8 patients (38,10%) with angioinvasion. Positive ER/PR in 11 patients (52,38%) and positive Her-2 in 10 patients (47,62%). PABC prognosis were: 8 patients (38,10%) in good condition, while 5 patients (23.81%) had distant metastasis, and 4 patients (19,05%) passed away. Twenty one babies born healthy (100%). The aggressiveness of PABC can be seen from the percentage of patients in advanced stage and has worse prognosis.Keywords: breast cancer, pregnancyABSTRAKPregnancy Associated Breast Cancer (PABC) merupakan keganasan yang paling sering ditemukan pada kehamilan. Karena agresivitas yang tinggi, PABC memerlukan penanganan yang khusus, baik saat penegakan diagnosis maupun tindakan terapi. Penelitian ini bertujuan mengetahui profil PABC di Rumah Sakit Onkologi Surabaya sejak 2006-2014. Studi deskriptif ini menggunakan data rekam medis pasien PABC sejak 2006 hingga 2014. Hasil penelitian menunjukkan kasus PABC sebanyak 21 pasien. Jumlah PABC tertinggi ditemukan pada usia 31-40 tahun, yaitu 11 pasien (52,38%); 16 pasien (76,19%) PABC didapatkan pada multiparitas; 14 pasien (66,67%) pada 1 tahun post-partum. Pada 18 pemeriksaan USG dan 6 pemeriksaan mammografi memiliki tingkat sensitivitas 100%; 14 pasien (66,67%) pada stadium III-IV; 9 pasien (42,86%) tumor T4; 12 pasien (57,14%) metastasis ke kelenjar getah bening; 4 pasien (19,05%) metastasis jauh; 10 pasien (47,62%) Invasive Ductal Carcinoma (IDC); 14 pasien (66,67%) pada grade III; 8 pasien (38,10%) memiliki angioinvasion; 11 pasien (52,38%) memiliki ER/PR positif; dan 10 pasien (47,62%) memiliki Her-2 positif. Pada follow up didapatkan 8 pasien (38,10%) berada dalam kondisi baik, 5 pasien mengalami metastasis jauh (23,81%), dan 4 pasien meninggal (19,05%). Dua puluh satu bayi terlahir sehat (100%). Kesimpulannya, agresivitas PABC dapat dilihat dari besarnya persentase pasien yang datang pada stadium lanjut dan prognosis yang buruk.Kata Kunci: kanker payudara, kehamilan
Keywords
breast cancer; pregnancy
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Article Info
Submitted: 2015-09-23
Published: 2015-07-01
Section: Research Articles
Article Statistics: 215 98