Kegemukan dan Frekuensi Konsumsi Makanan Berlemak yang Tinggi Merupakan Faktor Risiko Perlemakan Hati pada Pasien Kanker Payudara Dengan Pemeriksaan Ultrasonografi di Rumah Sakit Kanker Dharmais, Jakarta

BAHRIYATUL MA'RIFAH* -  Program Studi S1 Ilmu Gizi, Departemen Gizi Masyarakat, Fakultas Ekologi Manusia, Institut Pertanian Bogor, Bogor, Indonesia
EVY DAMAYANTHI -  Program Studi S1 Ilmu Gizi, Departemen Gizi Masyarakat, Fakultas Ekologi Manusia, Institut Pertanian Bogor, Bogor, Indonesia
KARDINAH KARDINAH -  , Indonesia

DOI : 10.33371/ijoc.v9i4.399

ABSTRACT
Fatty liver is a term applied to wide spectrum of conditions characterized hispatologically by trigliseride accumulation within the cytoplasm of hepatocytes which is examined using ultrasound. This study was aimed to identify the risk factors affecting fatty liver in the patients with breast cancer on ultrasound examination at Dharmais Cancer Hospital Jakarta. The design was a cross sectional study with 70 subjects, consisted of 37 fatty liver subjects and 33 normal subjects. The result showed that risk factors of fatty liver in patient with breast cancer were overweight and obesity (Body Mass Index ?25 kg/m2) (OR : 5.5, 95%CI : 1.881 16.243) and high frequency of dietary fat (OR: 3.8, 95%CI : 1.084
13.445).

ABSTRAK
Perlemakan hati merupakan akumulasi asam lemak dalam bentuk trigliserida di dalam sitoplasma hepatosit yang diperiksa dengan menggunakan alat ultrasonografi.Tujuan penelitian ini adalah untuk mengetahui faktor risiko yang berpengaruh terhadap kejadian perlemakan hati pada pasien kanker payudara dengan pemeriksaan ultrasonografi di Rumah Sakit Kanker Dharmais, Jakarta. Desain penelitian ini adalah cross sectional study, dengan subjek penelitian
berjumlah 70 orang yang terdiri dari 37 contoh perlemakan hati dan 33 contoh normal. Hasil analisis menunjukkan bahwa faktor risiko perlemakan hati pada pasien kanker payudara adalah kegemukan (overweight dan obes, Indeks Massa Tubuh ? 25 kg/m2) (OR=5.5, 95%CI : 1.881 16.243) dan tingginya frekuensi konsumsi makanan berlemak (OR=3.8, 95%CI : 1.084 13.455)

Keywords
breast cancer, fatty liver, ultrasound
  1. Departemen Kesehatan RI.Penyakit Tidak Menular [serial online] [cited 31 Des 2014];2012. Didapat dari URL:http:// www.depkes.go.id/download.php? file=download/pusdatin/buletin/buletin-ptm.pdf.
  2. Siegel R, Naishadham D, Jemal A. Cancer statistic 2012. Ca Cancer J Clin. 2012;62:1029.
  3. Globocan.Breast cancer incidence and mortality worldwide in 2008, International Agency for Research on Cancer, France [serial online] [cited 02 Apr 2015];2008. Didapat dari URL: http://globocan.iarc.fr.
  4. American Cancer Society.Breast cancer [serial online] [cited12 Jan 2015];2014. Didapat dariURL: http://www.cancer.org/Cancer/ BreastCancer/index.
  5. Waruna P. Hubungan perlemakan hati pada ultrasonografi dengan kepadatan payudara pada mammografi pasien kanker payudara di RS Kanker Dharmais [tesis].Jakarta: Universitas Indonesia, 2014.
  6. A. Takahashi, Katsushima F, Monoe K, Kanno Y, Saito H,Abe K, Ohira H. Estrogen reseptor expression by peripheral blood mononuclear cell of patient with non-alcoholic fatty liver disease. Journal of Hepatology 2011; 54:345-46.
  7. Chu SH, Lin SC, Shih Shou C, Kao CR, Chou SY. Fatty metamorphosis of the liver in patient with breast cancer :Possible associated factors. World J Gastroenterol 2003;9(7):1618-20
  8. Li G, Cheng Z, Wang C, Liu A, He Y, Wang P. Prevalence of and risk factors for non-alcoholic fatty liver disease in community-dwellers of Beijing, China. OA Evidence-Based Medicine 2013;1(1):10.
  9. Marchesini G, Ridolfi V, Nepoti V. Hepatotoxicity of fast food? Gut 2008; 57:568-70.
  10. World Gastroenterology Organisation.Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis [serial online] [cited 10 Jul 2015];2012.Didapat dari URL:http//www.NASH
  11. and NAFLD_Final_long.pdf.
  12. Riset Kesehatan Dasar. Laporan nasional 2013. Badan Penelitian dan Pengembangan Kesehatan, Departemen Kesehatan Rpublik Indonesia [serial online] [cited 3 Feb 2014];2013. Didapat dari URL: http//www.kemenkes.go.id/ download/riskesdas.
  13. Foster KJ, Dewbury KC, Griffith AH, Wright R. The accuracy of ultrasound in the detection of fatty infiltration of the liver.Br J Radiol 1980; 53:440-42.
  14. Saverymutu SH, Joseph AEA, Maxell JD.Ultrasound scanning in the detection of hepatic fibrosis and steatosis. J Br Med 1986; 292:13-15.
  15. Lanza FL, Nelson RS.Fatty metamorphosis of the liver in malignant neoplasia, special reference to carcionoma of the breast. Cancer 1968; 21:699-705.
  16. de Roos NM, Bots ML, Katan MB. Replacement of dietary saturated fatty acids by trans fatty acids lowers serum HDL cholesterol and impairsendothelial function in healthy men
  17. and women. Arterioscler ThrombVasc Biol 2001;21(7):1233-7.
  18. Lichtenstein AH, Appel LJ, Brands M, dkk. Diet and lifestyle recommendations revision. A scientific statement from the American Heart Association Nutrition Committee. Circulation
  19. ;114(1):82-96.
  20. Musso G, Gambino R, De Michieli F, dkk. Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis. Hepatology 2003; 37:909-16.
  21. Sekiya M, Yahagi N, Matsuzaka T, dkk. Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression. Hepatology 2003; 38:1529-39.
  22. Koswara S. Konsumsi lemak yang ideal bagi kesehatan[serial online] [28 Jan 2015]; 2010. Didapat dari: URL: http://www.ebookpangan.com/ARTIKEL/KONSUMSI%20 LEMAK%20YANG%20IDEAL.pdf
  23. Frantzides CT, Carlson MA, Moore RE,dkk. Effect of body mass index on non alcoholic fatty liver disease in patients undergoing minimally invasive bariatric surgery. Journal of Gastrointestinal Surgery 2004; 8(7):849-55.
  24. Fabbrini E, Sullivan S, Klein S. Obesity and non alcoholic fatty liver disease: biochemical, metabolic and clinical implications. J Hepatology 2010; 51(2):679-89.

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Article Info
Submitted: 2016-02-09
Published: 2015-12-05
Section: Research Articles
Article Statistics: 296 127