Hubungan antara Menyusui dengan Risiko Kanker Ovarium



Incidence of Ovarian Cancer, which has a high mortality rate, has been reported to increase since 2008 in Indonesia. A number of protective factors have been identified, one of which is breastfeeding. Despite this, published literature on the association of breastfeeding and ovarian cancer in Indonesia has not been found. The aim of this study is to determine the effect of breastfeeding on ovarian cancer in general, as well as among pre and post menopause patients. This case control study was done at “Dharmais”Cancer Hospital, involving 71 patients with ovarian cancer as the cases, and 140 cervical cancer patients who served as the controls. Interviews were done during follow-up visits. Patients, with adouble primary cancer,were not included in the study. The study shows that lifetime breastfeeding contributes to a decrease in the risk of ovarian cancer by 55% (OR=0.45, 95%CI 0.23 – 0.91) among all cases; the decrease was 53% (OR=0.47, 95%CI 0.23 – 0.96) for those who had previously given birth. These results were adjusted for level of education and menopause status at the time of diagnosis. Women with a history of breastfeeding have a lower risk of having ovarian cancer. The longer the duration of breastfeeding, the lower the risk of having ovarian cancer. The reduced risk was more than 50% for those with a lifetime breastfeeding of 24 months or more.


Insiden kanker ovarium yang memiliki tingkat letalitas tinggi, terus mengalami peningkatan sejak 2008. Beberapa faktor protektifnya telah diidentifkasi, salah satunya adalah menyusui. Meskipun begitu, penelitian yang membahas mengenai faktor tersebut belum banyak dilakukan. Untuk itu, penelitian ini bertujuan untuk mengetahui hubungan antara menyusui dengan risiko kanker ovarium, baik secara umum maupun pada kelompok pre-menopause dan postmenopause. Studi kasus kontrol ini dilakukan di Rumah Sakit Kanker “Dharmais” dengan kasus pasien kanker ovarium (N=71) dan kontrol pasien kanker serviks (n=140). Interview dilakukan pada pasien yang melakukan follow up visit. Pasien dengan kanker primer lain selain kanker ovarium (double primary cancer case) tidak diikutsertakan dalam studi. Hasil penelitian menunjukkan total durasi menyusui seumur hidup (lifetime breastfeeding) berhubungan dengan penurunan risiko terjadinya kanker ovarium sebesar 55% (OR=0,45; 95%CI 0,23–0,91). Pada semua responden yang pernah melahirkan, penurunan risiko sebesar 53% (OR=0,47; 95%CI 0,23–0,96). Nilai tersebut telah dikontrol terhadap variabel pendidikan dan status menopause saat didiagnosis. Penelitian ini menyimpulkan bahwa wanita dengan riwayat menyusui memiliki risiko yang lebih rendah untuk menderita kanker ovarium. Semakin lama durasi menyusui, semakin besar penurunan risiko terjadinya kanker ovarium, yaitu sebesar lebih dari 50% bagi mereka yang menyusui lebih dari 24 bulan.


breastfeeding, ovarian cancer, benefit of breastfeeding


IARC. Cancer Fact Sheet. Globocan 2012: Estimated Cancer Incidence, Mortality

and Prevalence Worldwide in 2012 [cited Maret 2016] didapat dari

Jemal A, Bray F, Center MM, et al. Global Cancer Statistics. CA Cancer J Clin 2011

Mar-Apr; 61(2): 69-90.

McLaughlin JR, Risch HA, Lubinski J et al. Reproductive risk factors for ovarian

cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study. Lancet

Oncology 2007 Jan;8(1):26-34

Anderson GL, Judd HL, Kaunitz AM, Barad DH, Beresford SA, Pettinger M, et al.

Effects of estrogen plus progestin on gynecologic cancers and associated diagnostic

procedures: the Women’s Health Initiative randomized trial. JAMA 2003 Oct; 290

(13): 1739-48.

Schildkraut JM, Bastos E, Berchuck A. Relationship between lifetime ovulatory cycles

and overexpression of mutant p53 in epithelial ovarian cancer. J Natl Cancer Inst


Siskind V, Green A, Bain C, et al. Breastfeeding, menopause, and epithelial ovarian

cancer. Epidemiology 1997;8:188-91.

Jordan SJ, Cushing-Haugen KL, Wicklund KG, et al. Breast feeding and risk of

epithelial ovarian cancer. Cancer Causes Control 2012;23:919-927.

Ernstoff LT, Perez K, Cramer DW, et al. Menstrual and reproductive factors in

relation to ovarian cancer risk. British Journal of Cancer 2001;84(5):714–721.

Zhang M, Lee AH, Binns CW. Reproductive and dietary risk factors for epithelial

ovarian cancer in China. Gynecol Oncol 2004;92:320-6.

Huusom LD, Frederiksen K, Hogdall EVS, Glud E, Christensen L, Hogdall CK,

Blaakaer J, Kjaer SK. Association of reproductive factors, oral contraceptive use and

selected lifestyle factors with the risk of ovarian borderline tumors: a Danish case

control study. Cancer Causes Control 2006;17:821-9.

Jordan SJ, Siskind V, Green AC, et al. Breastfeeding and risk of epithelial ovarian

cancer. Cancer Causes Control (2010)21:109–116.

Greggi S, Parazzini F, Paratore MP, Chatenoud L, Legge F, Mancuso S, La Vecchia C.

Risk factors for ovarian cancer in central Italy. Gynecol Oncology 2000;79:50-4.

Zhang M, Xie X, Lee AH, Binns CW. Prolonged lactation reduces ovarian cancer risk

in Chinese women. Eur J CancerPrev 2004;13:499-502.

Chiaffarino F, Pelucchi C, Negri E, et al. Breastfeeding and the risk of epithelial

ovarian cancer in an Italian population. Gynecol Oncology 2005;98:304-8.

Yen ML, Yen BL, Bai CH, et al. Risk factors for ovarian cancer in Taiwan: a

case-control study in a low-incidence population. Gynecol Oncology


Risch HA, Weiss NS, Lyon JL, Daling JR, Liff JM. Events of reproductive life and the

incidence of epithelial ovarian cancer. Am J Epidemiol 1983;117:128-39.

Gwinn ML, Lee NC, Rhodes PH, Layde PM, Rubin GL. Pregnancy, breastfeeding, and

oral contraceptives and the risk of epithelial ovarian cancer. J Clin Epidemiol


Liu J, Rebar RW, Yen SS. Neuroendocrine control of the post-partum period. Clin

Perinatol 1983;10:723-736.

Su D, Pasalich M, Lee AH, Binns CW. Ovarian cancer risk is reduced by prolonged

lactation: a case-control study in

Southern China. Am J Clin Nutr 2013;97:354-359.

Li DP, Du C, Zhang ZM et al. Breastfeeding and ovarian cancer

risk: A systematic review and meta-analysis of 40 epidemiological

studies. Asian Pac J Cancer Prev 2014;15:4829-4837.

Luan N, Wu Q, Gong T, et al. Breastfeeding and ovarian

cancer risk: a meta-analysis of epidemiologic studies. Am J

Clin Nutr 2013;98:1020–31.

Tung K, Wilkens LR, Wu AH, et al. Effect of Anovulation

Factors on Pre- and Postmenopausal Ovarian Cancer Risk:

Revisiting the Incessant Ovulation Hypothesis. Am J

Epidemiology 2005;161:321-329.

Gajalakshmi V, Mathew A, Brennan P, et al. Breastfeeding

and breast cancer risk in India: A multicenter case-control

study. Int. J. Cancer 2009;125(3):662–665.

Berek JS and Bast RC. Nonepithelial Ovarian Cancer. In Kufe

DW, Pollock RE, Weichselbaum RR, et al. (Editors). Holland-

Frei Cancer Medicine. 6th edition. Hamilton (ON): BC Decker;

WHO. Exclusive Breastfeeding. e-Library of Evidence for

Nutrition Actions (eLENA) [cited April 2016] didapat dari

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DOI: 10.33371/ijoc.v10i3.437

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