Profile of Breast Cancer Patients with Radiotherapy in Hasan Sadikin Hospital Bandung
Background: Breast cancer is the most common cancer in women worldwide and in Indonesia. Most patients arrived at the hospital too late to receive the optimal benefit from breast cancer therapies, in which radiotherapy is one of the essential modalities. Radiotherapy is conducted as a local control by using the principle of ionizing radiation to eradicate the growth of cancer cells, hence reducing the chances of recurrence and enhancing survival rates. Some of the side effects include skin conditions that can manifest as redness and dry skin, fatigue, lymphedema, and chest wall fibrosis. Data and research on the profile of breast cancer patients with radiotherapy were still limited in Indonesia, particularly in West Java. This study aimed to assess the profile of breast cancer patients in Hasan Sadikin Hospital Bandung.
Methods: This study was conducted with the retrospective descriptive quantitative method. The sampling technique was total sampling using 280 medical records of breast cancer patients with radiotherapy from January 1, 2018, until December 31, 2019, which were registered in the Hospital-Based Cancer Registry at the Radiotherapy Department, Hasan Sadikin General Hospital.
Results: Breast cancer patients undergoing radiotherapy were mostly in the 45–54 years age group (36.4%). The most common chief complaint was a lump in the breast (66.4%), particularly in the left breast (45.0%). About 22.5% of all patients arrived at a locally advanced stage and 30.7% at an advanced stage with bone metastasis (10.6%), histopathological subtype Invasive Carcinoma No Special Type (IC-NST) (81.1%), and molecular subtype luminal B (9.6%). The most widely performed therapies were total mastectomy surgery (16.1%), neoadjuvant chemotherapy (62.9%), and complete adjuvant radiotherapy (47.1%) with External Beam Radiotherapy (EBRT) method using LINAC (71.1%).
Conclusions: Breast cancer is a health burden in Hasan Sadikin General Hospital and remains one of the national health priorities. Further evaluation of management and follow-up studies need to be done to improve the implementation of therapies for patients and reduce the incidence rate
Article MetricsAbstract View: 317,
PDF Download: 202
Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov;68(6):394-424.
World Health Organization. Indonesia - Global Cancer Observatory [Internet]. 2021 [cited 2022 Jan 30]. Available from: https://gco.iarc.fr/today/data/factsheets/populations/360-indonesia-fact-sheets.pdf
Komite Penanggulangan Kanker Nasional (KPKN). Panduan Penatalaksanaan Kanker Payudara [Internet]. 2015 [cited 2022 Jan 30]. Available from: https://www.poijaya.org/wp-content/uploads/2021/03/PPKPayudara.pdf
Davidson NE. Breast Cancer and Benign Breast Disorders. In: RCSI Handbook of Clinical Surgery for Finals. Elsevier Inc.; 2020. p. 1319–26.
Wild CP, Weiderpass E, Stewart BW. World Cancer Report: Cancer Research for Cancer Prevention [Internet]. Lyon, France: International Agency for Research on Cancer; 2020 [cited 2020 Nov 30]. Available from: http://publications.iarc.fr/586
Washington CM, Leaver D. Principles and Practice of Radiation Therapy. 4th ed. Elsevier Ltd; 2016.
Dinas Kesehatan Provinsi Jawa Barat. Profil Kesehatan Jawa Barat 2017. 2018;154.
Shoemaker ML, White MC, Wu M, et al. Differences in breast cancer incidence among young women aged 20–49 years by stage and tumor characteristics, age, race, and ethnicity, 2004–2013. Breast Cancer Res Treat. 2018;169(3):595–606.
Lumintang L, Susanto A, Gadri R, Djatmiko A. Profil Pasien Kanker Payudara di Rumah Sakit Onkologi Surabaya, 2014. Indones J Cancer. 2015;9(3):105–110.
Zuraidah E, Edwar SQ. Oral Contraceptive as a Risk Factor of Breast Cancer in Female Patients at Dr. Cipto Mangunkusumo National Public Hospital, Jakarta, Indonesia in 2010-2014. International Journal of Innovative Science and Research Technology. 2020;5(5):1778–82.
Sun YS, Zhao Z, Yang ZN, et al. Risk factors and preventions of breast cancer. Int J Biol Sci. 2017;13(11):1387–97.
Valla M, Vatten LJ, Engstrøm MJ, et al. Molecular subtypes of breast cancer: Long-term incidence trends and prognostic differences. Cancer Epidemiol Biomarkers Prev. 2016;25(12):1625–34.
Nafissi N, Khayamzadeh M, Zeinali Z, et al. Epidemiology and Histopathology of Breast Cancer in Iran vs Other Middle Eastern Countries. Middle East J Cancer. 2018;9(3):243–51.
American Cancer Society. Breast Cancer Facts & Figures 2019-2020 [Internet]. Atlanta: American Cancer Society, Inc; 2019 [cited 2022 Jan 30]. Available from: https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/breast-cancer-facts-and-figures/breast-cancer-facts-and-figures-2019-2020.pdf
Viale G, Hanlon Newell AE, Walker E, et al. Ki-67 (30-9) scoring and differentiation of Luminal A- and Luminal B-like breast cancer subtypes. Breast Cancer Res Treat. 2019 Nov;178(2):451-458.
Rezano A, Pan CE, Istiqomah AA, Zada A. Association of Ki-67 Expression and Response of Neoadjuvant Chemotherapy in Invasive Breast Cancer Patients in Bandung. Int J Integr Heal Sci. 2018;6(2):80–83.
Vanamail P. Epidemiological profile of female breast cancer in reproductive age-group and its association with maternal characteristics: -A population-based observational study in India. Oncomedicine. 2019;4:27–34.
Badudu F, Suardi D, Ahmad D, et al. Challenges of locally advanced breast cancer in Hasan Sadikin Hospital Bandung Indonesia. The Breast. 2011;20:S52.
Sander MA. Profil Penderita Kanker Payudara Stadium Lanjut Baik Lokal Maupun Metastasis Jauh Di Rsup Hasan Sadikin Bandung. Farmasains J Farm dan Ilmu Kesehat. 2012;1(2).
Cheng SA, Liang LZ, Liang QL, et al. Breast cancer laterality and molecular subtype likely share a common risk factor. Cancer Manag Res. 2018 Nov 29;10:6549-6554.
Amer MH. Genetic factors and breast cancer laterality. Cancer Manag Res. 2014 Apr 16;6:191-203.
Syafri M, Rachmawati M, Istuti RDI. Karakteristik Penderita Kanker Payudara Berdasarkan Gambaran Histopatologi di RSUD Al-Ihsan Bandung Periode 2011-2014. Prosiding Pendidikan Dokter, UNISBA. 2019;1(1):1-5.
Kumar V, Abbas AK, Aster JC. Robbins Basic Pathology. 10th ed. Philadephia: Elsevier Inc.; 2018.
Tsuji W, Plock JA. Breast Cancer Metastasis. In: Aamir Ahmad, editor. Introduction to Cancer Metastasis. 1st ed. Elsevier; 2016. p.13–31.
Franceschini G, Martin Sanchez A, Di Leone A, et al. New trends in breast cancer surgery: a therapeutic approach increasingly efficacy and respectful of the patient. G Chir. 2015 Jul-Aug;36(4):145-52.
Yap ML, Zubizarreta E, Bray F, et al. Global Access to Radiotherapy Services: Have We Made Progress During the Past Decade? J Glob Oncol. 2016 Mar 16;2(4):207-215.
- There are currently no refbacks.